Premium
Microwave‐assisted Transition Metal‐catalyzed Coupling Approach to Indazole Diversity
Author(s) -
Oh Yoo Jin,
Yum Eul Kgun
Publication year - 2019
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11698
Subject(s) - indazole , aryl , combinatorial chemistry , catalysis , chemistry , palladium , suzuki reaction , transition metal , coupling (piping) , molecule , stereochemistry , organic chemistry , materials science , alkyl , metallurgy
Diverse mono or biaryl substituents were introduced to indazole moieties under microwave‐assisted palladium‐catalyzed coupling reactions with isomeric bromoindazoles and aryl boronic acids. 1,3‐Disubstituted indazoles were also obtained by CC or CN coupling of monosubstituted indazoles with functionalized terminal alkenes and arylhalides. Facile introduction of diverse substituents to indazoles showed useful synthetic approach for creating indazole compound library to discover biologically active small molecules.