Premium
The Cytotoxic Activity of Honokiol‐Triazole Derivatives in Ovarian Cancer Cells
Author(s) -
Preya Umma Hafsa,
Jeon Cheolmin,
Lee Haneul,
Kang Yujung,
Wang YiYue,
Choi JungHye,
Park Jeong Ho
Publication year - 2019
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11691
Subject(s) - honokiol , cytotoxic t cell , chemistry , ovarian cancer , cytotoxicity , 1,2,3 triazole , azide , apoptosis , triazole , click chemistry , reactive oxygen species , pharmacology , combinatorial chemistry , cancer research , biochemistry , in vitro , cancer , biology , medicine , organic chemistry
Honokiol‐triazole derivatives ( 4 – 17 ) were synthesized via click reactions between 2‐ or 4′‐propargylated honokiol and azide compounds. Their anticancer activities were evaluated by using two ovarian cancer cells (A2780 and OVCAR3). Among the 14 compounds, compound 5 coupled with 4′‐propargylated honokiol and benzyl azide exhibited relatively potent cytotoxic activity (IC 50 = 5.5 ± 0.5 μM for A2780 and IC 50 = 3.97 ± 0.6 μM for OVCAR3) but was less toxic to normal cells (IC 50 = 18.90 ± 0.9 μM for IOSE80PC). The cytotoxic effect of compound 5 is associated with caspase‐dependent apoptotic cell death via induction of intracellular reactive oxygen species.