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n ‐Butyllithium (1 mol %)‐catalyzed Hydroboration of Aldehydes and Ketones with Pinacolborane
Author(s) -
Yang Su Jin,
Jaladi Ashok Kumar,
Kim Jea Ho,
Gundeti Shankaraiah,
An Duk Keun
Publication year - 2019
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11635
Subject(s) - hydroboration , chemistry , butyllithium , catalysis , yield (engineering) , lithium (medication) , alkyl , ketone , organic chemistry , medicinal chemistry , medicine , materials science , metallurgy , endocrinology
A practical and efficient protocol for the hydroboration of aldehydes and ketones using a pinacolborane and alkyl lithium system is demonstrated. A systematic evaluation showed that 1 mol % n ‐butyllithium afforded catalyzed hydroboration of aldehydes and ketones in a short reaction time under ambient conditions. Excellent yield, functional group tolerance, short reaction time, low catalyst loading, and gram‐scale synthesis are the salient features of the proposed protocol.