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Positively and Negatively Charged Collagen Nanohydrogels: pH‐responsive Drug‐releasing Characteristics
Author(s) -
Kim HanSem,
Kim SungJin,
Kang JiHye,
Shin Ueon Sang
Publication year - 2018
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11412
Subject(s) - thermogravimetric analysis , chemistry , zeta potential , drug delivery , fourier transform infrared spectroscopy , gastrointestinal tract , bovine serum albumin , nuclear chemistry , drug , biophysics , chemical engineering , nanotechnology , chromatography , nanoparticle , organic chemistry , biochemistry , materials science , pharmacology , medicine , engineering , biology
Researchers are facing many challenges in developing a strategy for site‐specific delivery in the gastrointestinal tract that can maximize therapeutic response and reduce side effects. The objective of this article was to develop a site‐specific drug delivery system for the gastrointestinal tract using natural polymer collagen (CG). For this, two types of pH‐responsive CG nanohydrogels (negatively charged pH‐CGNH‐COOH and positively charged pH‐CGNH‐NH 2 ) were prepared using negatively and positively functionalized carbon nanotubes, CNT‐COOH and CNT‐NH 2 , respectively. The pH‐CGNH‐COOH and pH‐CGNH‐NH 2 nanohydrogel samples comprising negatively and positively charged fibrils (CG/CNT‐COOH and CG/CNT‐NH 2 ) were physicochemically characterized by Fourier‐transform infrared spectrometry, Zeta sizer, thermogravimetric analysis, and field emission scanning electron microscopy. They also revealed the pH‐responsive release of bovine serum albumin at pH 9 and cytochrome C at pH 2. These results strongly indicate that these drug carriers can be useful for site‐specific delivery in the gastrointestinal tract.