Synthesis, Characterization, and Enhanced Cancer‐Imaging Application of Trans‐activator of Transcription Peptide‐conjugated Ultrasmall Gadolinium Oxide Nanoparticles | Zendy

Ahmad Mohammad Yaseen | Zendy; Cha Hyunsil | Zendy; Oh InTaek | Zendy; Tegafaw Tirusew | Zendy; Miao Xu | Zendy; Ho Son Long | Zendy; Marasini Shanti | Zendy; Ghazanfari Adibehalsadat | Zendy; Yue Huan | Zendy; Chae Kwon Seok | Zendy; Chang Yongmin | Zendy; Lee Gang Ho | Zendy

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Synthesis, Characterization, and Enhanced Cancer‐Imaging Application of Trans‐activator of Transcription Peptide‐conjugated Ultrasmall Gadolinium Oxide Nanoparticles

Author(s) -

Ahmad Mohammad Yaseen,

Cha Hyunsil,

Oh InTaek,

Tegafaw Tirusew,

Miao Xu,

Ho Son Long,

Marasini Shanti,

Ghazanfari Adibehalsadat,

Yue Huan,

Chae Kwon Seok,

Chang Yongmin,

Lee Gang Ho

Publication year - 2018

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.11404

Subject(s) - in vivo , gadolinium , conjugated system , magnetic resonance imaging , chemistry , in vitro , peptide , cancer cell , materials science , nuclear magnetic resonance , nuclear chemistry , cancer , medicine , biochemistry , organic chemistry , physics , microbiology and biotechnology , radiology , biology , polymer

We prepared gadolinium oxide (Gd 2 O 3 ) nanoparticles (GNPs) coated with a trans‐activator of transcription (TAT) peptide with cell‐penetrating ability ( i.e ., TAT‐GNPs) through one‐pot process. We characterized the particle diameter, surface‐coating structure, water proton relaxivities, and in vitro cellular toxicities of the TAT‐GNPs. We measured in vivo T 1 magnetic resonance images (MRI) in a model nude mouse with liver cancer prior and posterior to intravenous administration. The average particle diameter of the GNPs was 1.5 nm. The sample solution exhibited a longitudinal water proton relaxivity (r 1 ) of 18.2/s/mM (r 2 /r 1 = 1.6, r 2 = transverse water proton relaxivity), which is four to five times higher than those of commercial Gd‐chelates. The in vivo T 1 MRI exhibited positively (or T 1 ) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT‐GNPs acted as an enhanced cancer‐imaging agent similar to the cancer‐targeting agent in T 1 MRI.

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