Premium
DQAsomes Nanoparticles Promote Osteogenic Differentiation of Human Adipose‐derived Mesenchymal Stem Cells
Author(s) -
Bae Yoonhee,
Jung Min Kyo,
Mun Ji Young,
Mallick Sudipta,
Song Su Jeong,
Kim Dong Min,
Ko Kyung Soo,
Han Jin,
Choi Joon Sig
Publication year - 2018
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11355
Subject(s) - mesenchymal stem cell , flow cytometry , adipose tissue , microbiology and biotechnology , propidium iodide , osteoblast , tissue engineering , stem cell , regeneration (biology) , chemistry , cancer research , biology , immunology , in vitro , medicine , biomedical engineering , apoptosis , biochemistry , programmed cell death
Mesenchymal stem cells (MSCs) can self‐renew and differentiate into multiple cell types. The delivery of drugs to MSCs is an important tool in the emerging fields of tissue regeneration and engineering. In this study, we determined the anticancer efficiency of DQAsomes, which displayed affinity toward human adipose‐derived mesenchymal stem cells (AD‐MSCs). Cytotoxicity assays were conducted to examine human AD‐MSCs. We also evaluated the cellular effects of human AD‐MSCs treated with DQAsomes by cell cycle distribution analysis, annexin‐V propidium iodide staining, and H2DCFDA and found that DQAsomes promoted the differentiation of AD‐MSCs into osteoblast cells. Furthermore, flow cytometry analysis revealed that human AD‐MSCs treated with DQAsomes maintained the phenotypic characteristics of human AD‐MSCs. We demonstrated that DQAsomes can be used in tissue engineering and have clinical relevance as effective drug and protein delivery systems.