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Efficient Synthesis and Characterization of Monoprotected Symmetrical Poly(Ethylene Glycol) Diamine
Author(s) -
Jeong Hyeri,
Youn Dayoung,
Nam Jihye,
Kim Jaehi,
Lee YoonSik,
Shin DongSik
Publication year - 2018
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11335
Subject(s) - diamine , ethylene glycol , peg ratio , ethylene diamine , polyethylene glycol , chemistry , electrospray ionization , mass spectrometry , characterization (materials science) , molecule , polymer chemistry , combinatorial chemistry , chromatography , organic chemistry , materials science , nuclear chemistry , nanotechnology , finance , economics
Solid‐phase synthesis of monoprotected poly(ethylene glycol) (PEG) diamine is demonstrated. 2‐Chlorotrityl chloride (2‐CTC) resin was used as a solid support for inducing monofunctionalization using excess PEG diamine. Fmoc‐monoprotected PEG was prepared from 2‐CTC resin and fully characterized by high‐performance liquid chromatography and electrospray ionization mass spectrometry. We envision that this strategy will provide an efficient method of preparing various kinds of heterobifunctional PEG molecules without a need for further purification steps.