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Anticancer Activity of 2‐Amino‐substituted‐1,4‐naphthoquinone Derivatives in Ovarian Cancer Cells
Author(s) -
Shin Sujeong,
Lee Haneul,
Jeon Cheolmin,
Preya Umma Hafsa,
Choi JungHye,
Park Jeong Ho
Publication year - 2017
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11315
Subject(s) - moiety , chemistry , ovarian cancer , cytotoxic t cell , naphthoquinone , chelation , combinatorial chemistry , catalysis , stereochemistry , cancer , biochemistry , in vitro , organic chemistry , medicine
2‐Amino‐substituted‐1,4‐naphthoquinone derivatives ( 10 – 17 ) were synthesized from coupling reaction between 1,4‐dihydroxynaphthalene and amines in the presence of catalyst CeCl 3 . 7H 2 O. Their anticancer activity was evaluated by using three ovarian cancer cells (A2780, SKOV3, and OVCAR3). Among the eight compounds, compound 13 containing metal chelating moiety had a relatively potent cytotoxic activity (IC 50 < 10 μM) on all three ovarian cancer cells.