Anticancer Activity of 2‐Amino‐substituted‐1,4‐naphthoquinone Derivatives in Ovarian Cancer Cells | Zendy

Shin Sujeong | Zendy; Lee Haneul | Zendy; Jeon Cheolmin | Zendy; Preya Umma Hafsa | Zendy; Choi JungHye | Zendy; Park Jeong Ho | Zendy

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Anticancer Activity of 2‐Amino‐substituted‐1,4‐naphthoquinone Derivatives in Ovarian Cancer Cells

Author(s) -

Shin Sujeong,

Lee Haneul,

Jeon Cheolmin,

Preya Umma Hafsa,

Choi JungHye,

Park Jeong Ho

Publication year - 2017

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.11315

Subject(s) - moiety , chemistry , ovarian cancer , cytotoxic t cell , naphthoquinone , chelation , combinatorial chemistry , catalysis , stereochemistry , cancer , biochemistry , in vitro , organic chemistry , medicine

2‐Amino‐substituted‐1,4‐naphthoquinone derivatives ( 10 – 17 ) were synthesized from coupling reaction between 1,4‐dihydroxynaphthalene and amines in the presence of catalyst CeCl 3 . 7H 2 O. Their anticancer activity was evaluated by using three ovarian cancer cells (A2780, SKOV3, and OVCAR3). Among the eight compounds, compound 13 containing metal chelating moiety had a relatively potent cytotoxic activity (IC 50 < 10 μM) on all three ovarian cancer cells.

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