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Synthesis and Evaluation of Novel 3‐Allylseleno‐6‐Alkylsulfonylpyridazine Derivatives with Potential Anticancer Properties
Author(s) -
Kim Chaewon,
Park MyungSook
Publication year - 2017
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11292
Subject(s) - ethanethiol , pyridazine , chemistry , human breast , cancer cell lines , cancer cell , cell culture , cancer , cancer research , combinatorial chemistry , stereochemistry , pharmacology , biochemistry , medicine , biology , organic chemistry , genetics
A new series of 3‐allylseleno‐6‐alkylsulfonylpyridazines and 3‐allylseleno‐6‐alkylsulfinylpyridazines were synthesized from 3,6‐dichloropyridazine for anticancer agent development. The inhibitory effects of 3‐allylseleno‐6‐alkylsulfonylpyridazines on human cancer cell lines were investigated. The synthesis involved thiolation, oxidation, selenylation, and Se‐allylation of alkylthiols. That is, sodium methanethiolate, ethanethiol, propanethiol, butanethiol, pentanethiol, and hexanethiol were inserted into the 6‐position of the pyridazine nucleus. These new synthetic compounds exhibited antiproliferative activity against human breast cancer ( MCF ‐7), hepatocarcinoma ( Hep3B ), and human colon carcinoma ( RKO ) cells in CCK ‐8 assays, and are potential candidates for cancer chemotherapy.