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Carbothioamide as Highly Efficient Ligand for Copper‐catalyzed Room Temperature Chan–Lam Cross‐Coupling Reaction
Author(s) -
Baruah Jayantajit,
Gogoi Kongkona,
Dewan Anindita,
Borah Geetika,
Bora Utpal
Publication year - 2017
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11248
Subject(s) - catalysis , chemistry , copper , ligand (biochemistry) , homogeneous , combinatorial chemistry , coupling reaction , ethanol , reaction conditions , coupling (piping) , medicinal chemistry , organic chemistry , materials science , metallurgy , receptor , mathematics , biochemistry , combinatorics
The catalytic activity of three N,S‐donor ligands, viz L1 [2‐(4‐methoxybenzylidene)‐ N ‐phenylhydrazinecarbothioamide], L2 [2,2′‐(1,2‐diphenylethane‐1,2‐diylidene)bis(hydrazinecarbothioamide)] and L3 [2‐(4‐methoxybenzylidene)hydrazinecarbothioamide] has been reported for N‐arylation of imidazoles with arylboronic acids in ethanol at room temperature. The method was found to be applicable in N‐arylation for a wide range of electronically diverse arylboronic acids with imidazoles having modest to excellent isolated yields. The in situ generated copper( II ) complex of the ligand namely, 2‐(4‐methoxybenzylidene)‐ N ‐phenylhydrazinecarbothioamide ( L1 ) was found to be highly efficient homogeneous catalyst for N‐arylation reaction.