Inhibitory Activity of Halogenated 3‐Benzylidenechroman‐4‐ones Against Lipopolysaccharide‐stimulated Reactive Oxygen Species Production in  RAW  264.7 Macrophages | Zendy

Thapa Magar Til Bahadur | Zendy; Kadayat Tara Man | Zendy; Oh Hye Jin | Zendy; Park PilHoon | Zendy; Lee EungSeok | Zendy

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Inhibitory Activity of Halogenated 3‐Benzylidenechroman‐4‐ones Against Lipopolysaccharide‐stimulated Reactive Oxygen Species Production in RAW 264.7 Macrophages

Author(s) -

Thapa Magar Til Bahadur,

Kadayat Tara Man,

Oh Hye Jin,

Park PilHoon,

Lee EungSeok

Publication year - 2017

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.11147

Subject(s) - lipopolysaccharide , reactive oxygen species , chemistry , inhibitory postsynaptic potential , ic50 , halogen , oxygen , active oxygen , in vitro , biochemistry , biology , organic chemistry , immunology , endocrinology , alkyl

Chromanone‐containing compounds have been reported to possess several important biological activities. As a part of our continuing effort for discovering potent anti‐inflammatory agents, a series of halogen‐containing 3‐benzylidenechroman‐4‐ones ( 1–15 ) were synthesized, and evaluated for their inhibitory effect on lipopolysaccharide ( LPS )‐stimulated reactive oxygen species ( ROS ) production in RAW 264.7 macrophages. Compounds 4 and 10 exhibited significant inhibitory activity ( IC 50 = 5.09 ± 1.27 and 5.11 ± 0.51 μM , respectively) against LPS ‐stimulated ROS production in RAW 264.7 macrophages.

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