Facile Synthesis of 2‐Amino‐4‐alkoxypyrimidines via Consecutive Nucleophilic Aromatic Substitution ( S N Ar ) Reactions

A transition‐metal‐free and regioselective synthesis of a series of 2‐amino‐4‐alkoxypyrimidines is described. The S N Ar alkoxylation of 2,4‐dichloropyrimidines regioselectively provided 2‐chloro‐4‐alkoxypyrimidines, which were subsequently subject to the second S N Ar amination with cyclic amines in the presence of triethylamine at high temperature to afford 2‐amino‐4‐alkoxypyrimidines in good overall yield.