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Preparation of Hydroxypropyl Cyclosophoraose/Dextran Microspheres for the Controlled Release of Ciprofloxacin
Author(s) -
Lee Benel,
Jeong Daham,
Joo SangWoo,
Choi Jae Min,
Lee Jae Yung,
Cho Eunae,
Park Seyeon,
Jung Seunho
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11001
Subject(s) - dextran , chemistry , fourier transform infrared spectroscopy , drug carrier , drug delivery , controlled release , nuclear chemistry , microsphere , chromatography , chemical engineering , materials science , nanotechnology , organic chemistry , engineering
Hydroxypropyl cyclosophoraose/dextran ( HPCys /dextran) microspheres were prepared using an emulsion polymerization method for use as drug carriers to achieve the controlled release of a poorly water‐soluble antibacterial drug, ciprofloxacin ( CFX ). Cyclosophoraoses are cyclic (1 → 2)‐β‐ d ‐glucans isolated from the Rhizobium species. Characteristics of HPCys /dextran microspheres were investigated using Fourier transform infrared analysis, solid‐state 13 C nuclear magnetic resonance spectroscopy, and field emission scanning electron microscopy. The amount of CFX released from these microspheres at pH 7.4 (intestinal phase pH ) was about two times higher than that released at pH 1.2 (gastric phase pH ). Furthermore, HPCys /dextran microspheres did not show any toxicity in human embryonic kidney cells. We propose that HPCys /dextran microspheres could be used as an effective pH ‐dependent release system for poorly water‐soluble drugs such as CFX .
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