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Efficient Synthesis and Stimulatory Effect of C‐10 Exo‐methylene Artemisinin on MC3T3‐E1 Preosteoblast Differentiation to Osteoblasts
Author(s) -
Park Sangkyu,
Namkung Jun,
Oh Sangtae,
Lee Seokjoon
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10998
Subject(s) - runx2 , artemisinin , methylene blue , chemistry , methylene , microbiology and biotechnology , transcription factor , osteoblast , gene , biochemistry , biology , medicinal chemistry , in vitro , immunology , catalysis , plasmodium falciparum , photocatalysis , malaria
C‐10 exo ‐methylene artemisinin ( 9 ) increase s the expression of ALP , an early differentiation marker of osteogenesis, and transcription factors including Runx2 and Osx that regulate osteogenic gene expression.