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Rhamnetin Exhibits Anti‐Tuberculosis Activity and Protects against Lung Inflammation
Author(s) -
Kim Min Jun,
Jeon Dasom,
Kwak Chulhee,
Ryoo Sungweon,
Kim Yangmee
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10958
Subject(s) - pharmacology , tumor necrosis factor alpha , inflammation , p38 mitogen activated protein kinases , antimycobacterial , medicine , mycobacterium tuberculosis , kinase , chemistry , immunology , protein kinase a , tuberculosis , biochemistry , pathology
Rhamnetin, a natural flavonoid found in cloves and berries has been reported to show anti‐inflammatory activities in lipopolysaccharide‐stimulated RAW264 .7 cells and may be a potent inhibitor for extracellular signal‐regulated kinase 1 ( ERK1 ) and c‐Jun N‐terminal kinase. Here, we showed that rhamnetin has antimycobacterial effects on Mycobacterium tuberculosis ( MT ) H 37 Rv , multi‐drug‐, and extensively drug‐resistant clinical isolates. We also investigated the effect of rhamnetin on interferon ( IFN )‐γ‐stimulated human lung fibroblast MRC ‐5 cells, since MT infection causes intensive lung inflammation. Rhamnetin suppressed mRNA levels of tumor necrosis factor‐α, interleukin ( IL )‐1β, IL ‐6, IL ‐12, and matrix metalloproteinase‐1. Furthermore, it inhibited IFN ‐γ‐mediated stimulation of ERK1 and p38 mitogen‐activated protein kinase in MRC ‐5 cells. These results showed that rhamnetin has potent anti‐tuberculosis activities and effectively suppresses lung inflammation, implying that rhamnetin can be a potent anti‐tuberculosis dietary agent.