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A New Kaempferol‐based Ru( II ) Coordination Complex, Ru(kaem)Cl( DMSO ) 3 : Structure and Absorption–Emission Spectroscopy Study
Author(s) -
Shao Mingwei,
Gang Jongback,
Kim Sanghyo,
Yoon Minyoung
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10916
Subject(s) - chemistry , kaempferol , stacking , crystal structure , crystallography , absorption spectroscopy , spectroscopy , dimer , metal , fluorescence spectroscopy , stereochemistry , fluorescence , photochemistry , organic chemistry , flavonoid , physics , antioxidant , quantum mechanics
Recent interest in developing a new anticancer drug with low side effects has led to the study of the combination of two new anticancer drugs. Although both kaempferol (kaem) and Ru‐based metal complexes have not been proven as effective drugs, their unique anticancer activities with reduced side effects have drawn our attention to the need for further studies on their potential in anticancer application. Herein, we report the synthesis, characterization, structure, and spectroscopic properties of a kaem‐based Ru ( II ) complex, RuCl (kaem)( DMSO ) 3 ( 1 ). Because of the presence of a catechol‐like functional group in its dihydropyran ring, kaem can strongly bind to the Ru( II ) metal center in a basic medium. The molecular structure of the complex was characterized by spectroscopic studies and X‐ray crystal structure analysis. In addition, the complex forms a molecular dimer as a result of the cooperative effect of H‐bonding and π–π stacking interactions. Moreover, the molecular dimer forms a ladder‐like one‐dimensional network structure by water mediated H‐bonding that further extended into a three‐dimensional packing structure. UV –Vis spectroscopy studies of the complex demonstrated the appearance of a strong metal to ligand charge transfer ( MLCT ) band in the visible region with strong fluorescence emission derived from the MLCT . Further studies are now in progress to demonstrate synergetic anticancer activity.