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Quercetin 7‐ O ‐Glutamate Potentiates Staphylococcus aureus to Fluoroquinolone Antibiotics
Author(s) -
Park KwangSu,
Choo Hyunah,
Kim Mi Kyoung,
Chong Youhoon
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10901
Subject(s) - staphylococcus aureus , antibiotics , efflux , ciprofloxacin , chemistry , antibacterial activity , microbiology and biotechnology , quercetin , long term potentiation , pharmacology , bacteria , medicine , biology , biochemistry , receptor , genetics , antioxidant
The quercetin conjugate Q‐7‐O‐Glu (5) showed inhibition of NorA efflux pump and thereby potentiation of antibacterial activity of various antibiotics against S. aureus . In particular, upon combination with 5, the fluoroquinolone antibiotics (ciprofloxacin) showed 4‐times enhanced antibacterial activity against S. aureus .