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Novel Synthesis of Tryptamine Derived 4‐Hydroxy‐4‐arylthiazolidine‐2‐thiones and 4‐Arylthiazole‐2(3 H )‐thiones by Multicomponent Reactions
Author(s) -
Devi Nepram Sushuma,
Singh Sarangthem Joychandra,
Mahiya Kuldeep,
Singh Okram Mukherjee,
Choi Hojune,
Lee SangGyeong
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10892
Subject(s) - tryptamine , chemistry , carbon disulfide , phenacyl bromide , bromide , phenacyl , reaction conditions , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , biochemistry
An efficient one‐pot multicomponent synthesis of 3‐(2‐(1 H ‐indol‐3‐yl)ethyl)‐4‐hydroxy‐4‐arylthiazolidine‐2‐thione and 3‐(2‐(1 H‐ indol‐3‐yl)ethyl)‐4‐arylthiazole‐2(3 H )‐thione has been developed from a multicomponent reaction of tryptamine, carbon disulfide and phenacyl bromide. This protocol has an advantage such as operational simplicity, short reaction time, and affording good to excellent yields.

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