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Temperature‐responsive Hydrogels Synthesized from Photo‐Polymerizable Poloxamer Macromers for Topical Skin Moisturizing
Author(s) -
Lee Jun Bae,
Lee Yea Ram,
Nam Yoon Sung,
Kim Jin Woong
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10865
Subject(s) - self healing hydrogels , poloxamer , copolymer , swelling , polymerization , polymer chemistry , aqueous solution , materials science , chemistry , chemical engineering , polymer , organic chemistry , composite material , engineering
Temperature‐responsive hydrogels were fabricated by the photo‐polymerization of bis‐acryloyl poloxamer tri‐block copolymers, and their temperature‐responsive behavior and physiological effect on skin were investigated. For this, poloxamer macromers were prepared by end‐capping both terminal hydroxyl groups of poloxamer tri‐block copolymers with acrylates. They were then photo‐polymerized to generate polymeric hydrogels with structural integrity that allowed excellent stability against dilution in an aqueous environment. The resulting hydrogels exhibited dramatic reversible swelling behavior upon changes in temperature. A demonstration experiment, in which the hydrogels were applied topically to the skin, showed that they shrank rapidly as a result of the increase in temperature, owing to the contact with the skin surface, highlighting their effectiveness for instantaneously moisturizing the skin.