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Paper Strip‐based Fluorometric Determination of Cyanide with an Internal Reference
Author(s) -
Lee DongNam,
Seo Hyejin,
Shin IkSoo,
Hong JongIn
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10863
Subject(s) - cyanide , malononitrile , nitrile , chemistry , gold cyanidation , electrophile , acceptor , photochemistry , inorganic chemistry , organic chemistry , catalysis , physics , condensed matter physics
The rapid, selective, and sensitive determination of cyanide anion ( CN − ) using a simple paper strip is highly attractive because cyanide is acutely lethal to living organisms via all routes of administration, including alcohol consumption and inhaling cigarette smoke. Here, a synthetic probe ( 1 ) was designed for the selective determination of cyanide. The probe displays rapid and large blue spectral change (Δλ abs =148 nm, Δλ em = 165 nm) with respect to target recognition. Probe 1 exhibits a strong push–pull electronic effect and comprises a dimethylaminoaryl group as a donor and malononitrile as an acceptor; the π‐conjugation system can be destroyed by the Michael‐type addition of cyanide at the electrophilic β‐positions of the nitrile groups, resulting in the marked emergence of a peak at λ em = 515 nm. The developed probe was successfully applied to a paper test strip because of its noticeable optical changes upon reaction with cyanide. The fabricated dumbbell‐shaped paper strip with an internal reference allowed the cyanide detection, which is indispensable for quantitative analysis in point‐of‐care testing. The paper strip test showed selective response to cyanide, with a linear correlation in the range of 0–25 mM in a simple and cost‐effective manner.