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Development of Cationic Liposomes for Enhanced Algicidal Efficacy of the Novel Algicidal Agent DP92
Author(s) -
Cho Yujin,
Cho Kwan Hyung,
Cho Hoon,
Jee JunPil
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10829
Subject(s) - liposome , heterosigma akashiwo , chemistry , cationic polymerization , cationic liposome , solubility , algal bloom , chromatography , biochemistry , organic chemistry , genetic enhancement , phytoplankton , nutrient , gene
We have developed liposomes modified with various surface‐charged lipids in order to solubilize the new algicidal agent, N ‐[(3,4‐dichlorophenyl)methyl]cyclohexanamine ( DP92 ), and enhance its algicidal activity against harmful algal blooms ( HABs ). The effect of liposome surface charge on algicidal activity was evaluated by using positively charged and neutral liposomes. The algicidal activity of the developed liposomes was evaluated by monitoring the inhibition of the growth rates of HABs ( Heterosigma circularisquama ( HC ) and Heterosigma akashiwo ( HA )). The algicidal activity of the liposomes was 2–6 times stronger compared to that of control. The solubilization of DP92 by entrapment in liposomes increased the solubility of DP92 and improved its algicidal activity up to sixfold. The electrostatic interaction between the negatively charged cell walls of HABs and the cationic liposomes additionally enhanced the algicidal activity of DP92 .