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Enantiomer Separation of Acidic Chiral Compounds on a tert ‐Butylcarbamoylquinine‐Silica Hybrid Monolith by Capillary Electrochromatography
Author(s) -
Tran Le Ngoc,
Jeong JeongAe,
Park Jung Hag
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10820
Subject(s) - triethylamine , chemistry , enantiomer , capillary electrochromatography , monolith , methanol , acetic acid , acetonitrile , capillary electrophoresis , monomer , chromatography , silica gel , nuclear chemistry , organic chemistry , catalysis , polymer
A tert ‐butylcarbamoylquinine ( t BuCQUI )‐incorporated silica hybrid monolithic ( QUI–SHM ) capillary was prepared by “one‐pot” approach via simultaneous sol–gel reaction of tetramethoxysilane and vinyltrimethoxysilane and free radical polymerization of t BuCQUI . A set of acidic chiral drugs were enantioseparated on QUI–SHM in mobile phases consisting of acetonitrile ( ACN ), methanol ( MeOH ), acetic acid ( AcOH ), and triethylamine ( TEA ). Influences of ACN / MeOH ratio, AcOH / TEA ratio, and their concentrations on enantioseparation were investigated. Baseline separations of enantiomers of all the compounds investigated were achieved with a mobile phase of 60:38 (v/v) ACN / MeOH containing 350 mM AcOH and 30 mM TEA under the applied voltage of −10 kV at 25°C.