Enantiomer Separation of Acidic Chiral Compounds on a  tert ‐Butylcarbamoylquinine‐Silica Hybrid Monolith by Capillary Electrochromatography | Zendy

Tran Le Ngoc | Zendy; Jeong JeongAe | Zendy; Park Jung Hag | Zendy

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Enantiomer Separation of Acidic Chiral Compounds on a tert ‐Butylcarbamoylquinine‐Silica Hybrid Monolith by Capillary Electrochromatography

Author(s) -

Tran Le Ngoc,

Jeong JeongAe,

Park Jung Hag

Publication year - 2016

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.10820

Subject(s) - triethylamine , chemistry , enantiomer , capillary electrochromatography , monolith , methanol , acetic acid , acetonitrile , capillary electrophoresis , monomer , chromatography , silica gel , nuclear chemistry , organic chemistry , catalysis , polymer

A tert ‐butylcarbamoylquinine ( t BuCQUI )‐incorporated silica hybrid monolithic ( QUI–SHM ) capillary was prepared by “one‐pot” approach via simultaneous sol–gel reaction of tetramethoxysilane and vinyltrimethoxysilane and free radical polymerization of t BuCQUI . A set of acidic chiral drugs were enantioseparated on QUI–SHM in mobile phases consisting of acetonitrile ( ACN ), methanol ( MeOH ), acetic acid ( AcOH ), and triethylamine ( TEA ). Influences of ACN / MeOH ratio, AcOH / TEA ratio, and their concentrations on enantioseparation were investigated. Baseline separations of enantiomers of all the compounds investigated were achieved with a mobile phase of 60:38 (v/v) ACN / MeOH containing 350 mM AcOH and 30 mM TEA under the applied voltage of −10 kV at 25°C.

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