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Antiobesity Effect of SA37 in High‐Fat Diet‐induced Obese C57BL / 6J Mice
Author(s) -
Kafle Bhooshan,
Khadka Deegendra,
Park Byung Ho,
Kim Chan Kyung,
Cho Hyeongjin
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10730
Subject(s) - chemistry , potency , endocrinology , medicine , phosphatase , inhibitory postsynaptic potential , knockout mouse , protein tyrosine phosphatase , kinase , biochemistry , enzyme , receptor , biology , in vitro
SA37 inhibits protein tyrosine phosphatase 1B ( PTP1B ) with a medium potency, and inhibits IκB kinase β ( IKKβ ) at a submicromolar half‐maximal inhibitory concentration. In animal study, SA37 reduced diet‐induced weight gain in mice, without significantly ameliorating glucose tolerance and lipid parameters. These observations coincide partly with PTP1B knockout but are inconsistent with IKKβ depletion in mice. The effect of SA37 on high‐fat diet ( HFD )‐induced obese mice was compared with previous results obtained by the authors’ group on a series of SA compounds that exhibited different inhibitory potencies toward IKKβ and PTP1B .