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Electrochemically Inducible Surfaces for Patterning Two Distinct Molecules
Author(s) -
Choi Inseong,
Yeo WoonSeok
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10721
Subject(s) - amine gas treating , chemistry , monolayer , acetylene , molecule , electrochemistry , combinatorial chemistry , self assembled monolayer , ligand (biochemistry) , click chemistry , cyclic voltammetry , photochemistry , chemical reaction , organic chemistry , electrode , biochemistry , receptor
Herein, we report on a new multicomponent patterning method based on electrochemically inducible self‐assembled monolayers on gold. Two different masked functional groups on monolayers are activated to give amine and acetylene moieties through electrochemical activations at negative potential and positive potential, respectively. The resulting amine and acetylene groups are further used as chemical handles for incorporation of ligand molecules via well‐known chemoselective conjugation reactions such as amine‐specific conjugation chemistry and click reaction. The chemical conversions of masked functional groups to amine and acetylene groups were characterized by cyclic voltammetry. We demonstrated the orthogonal immobilization of two fluorescent dyes on the patterned surface along the patterned features. Our strategy can provide a useful platform technology for the preparation of multicomponent ligand‐patterned substrates with various advantages such as chemical flexibility, mild reaction conditions, and high yields of two orthogonal chemical reactions of amine‐specific conjugation and click reaction.