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Core–Shell Structured Chitosan–Carbon Nanotube Membrane as a Positively Charged Drug Delivery System: Selective Loading and Releasing Profiles for Bovine Serum Albumin
Author(s) -
Kim HanSem,
Shin Ueon Sang
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10712
Subject(s) - bovine serum albumin , carbon nanotube , membrane , chemical engineering , chitosan , scanning electron microscope , adsorption , buckypaper , drug delivery , chemistry , materials science , nanocomposite , nanotechnology , chromatography , composite material , organic chemistry , biochemistry , engineering
Here we present carbon nanotube ( CNT ) buckypaper with efficient loading and releasing patterns for negatively charged drug. Carbonaceous membrane (Chit– NH 2 / CNT ) with three‐dimensionally interwoven porous nanostructure and positive surface was prepared by self‐assembly of CNT fibers hybridized with chitosan (Chit– NH 2 ) in core–shell structure. Transmission electron microscopy and scanning electron microscopy images clearly showed that core–shell structured Chit– NH 2 / CNT fibers and countless nanosized pores at less than 30 nm in length were formed between positively charged Chit– NH 2 / CNT fibers. Based on Brunauer–Emmett–Teller N 2 ‐adsorption method, the surface area, average pore size, and pore volume were approximately 19.7 m 2 /g, 9.54 nm, and 0.043 cc/g, respectively. Bovine serum albumin ( BSA ) loading and releasing profiles of these carbonaceous membrane constructed with positively charged CNT fibers were tested. The maximum entrapment of BSA was at a loading capacity of 0.65 mg/mg for 1.0 mg of Chit– NH 2 / CNT hybrid membrane. The maximum release of BSA was about 65% of the entrapped amount for 1.0 mg of Chit– NH 2 / CNT hybrid membrane. BSA was almost continuously released over the 11‐day period at a rate of about 0.23 g/day. Chit– NH 2 / CNT hybrid membranes showing impressive drug‐loading/‐releasing characteristics could be potentially used as transdermal drug delivery system for negatively charged drugs in the medicinal field and tissue regeneration area.