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Asymmetric Alkylation Reactions Using Non‐Cross‐Linked Polystyrene‐supported 2‐Imidazolidinone Chiral Auxiliary Derived from l ‐Phenyl Alanine
Author(s) -
Kang Byung Sun,
Kim Taek Hyeon
Publication year - 2016
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10699
Subject(s) - alkylation , polystyrene , yield (engineering) , chiral auxiliary , chemistry , cleavage (geology) , polymer , organic chemistry , polymer chemistry , enantioselective synthesis , catalysis , materials science , composite material , fracture (geology) , metallurgy
The non‐cross‐linked polystyrene (NCPS)‐supported 2‐imidazolidinone chiral auxiliary, based on a new anchoring strategy, afforded excellent diastereocontrol and yield in asymmetric alkylation reactions. The cleavage of this soluble, polymer‐supported chiral auxiliary 8 produced highly optical pure carboxylic acids and strong polymer recovery.