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Development of Hydrogel Lenses with Surface‐immobilized PEG Layers to Reduce Protein Adsorption
Author(s) -
Jee JunPil,
Kim HoJoong
Publication year - 2015
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10545
Subject(s) - self healing hydrogels , peg ratio , protein adsorption , ethylene glycol , adsorption , chemical engineering , chemistry , methacrylate , polymer chemistry , lysozyme , surface modification , materials science , polymer , organic chemistry , polymerization , biochemistry , finance , engineering , economics
Novel tri‐branched poly(ethylene glycol) ( PEG )‐substituted benzohydrazides were synthesized and used as building blocks for the preparation of protein‐resistant hydrogels via surface modifications. The PEG ‐modified hydrogels exhibited high transparency and improved surface hydrophilicity compared to the untreated hydrogels. Notably, such hydrogels significantly reduced the adsorption of proteins from tear fluid.