Folate‐decorated Polysaccharide‐doxorubicin Polymer: Synthesis, Characterization, and Activity in  HeLa  Cells | Zendy

Zhang Lei | Zendy; Guo Lulu | Zendy; Ding Jingna | Zendy; Lu Yongming | Zendy; Zhang Yaping | Zendy; Chen Yan | Zendy

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Folate‐decorated Polysaccharide‐doxorubicin Polymer: Synthesis, Characterization, and Activity in HeLa Cells

Author(s) -

Zhang Lei,

Guo Lulu,

Ding Jingna,

Lu Yongming,

Zhang Yaping,

Chen Yan

Publication year - 2015

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.10386

Subject(s) - lentinan , hela , doxorubicin , cytotoxicity , chemistry , prodrug , drug delivery , polysaccharide , in vitro , biochemistry , pharmacology , combinatorial chemistry , chemotherapy , biology , organic chemistry , genetics

In order to develop the application of the natural polysaccharide lentinan (LNT) and decrease the side effects of doxorubicin, we successfully synthesized a novel folate‐modified maleilated lentinan‐doxorubicin ( FA ‐M. LNT‐DOX ) polymer and used it for tumor‐targeted drug delivery. The release efficiency and cytotoxicity of the prodrugs were evaluated in vitro . Although DOX release from FA ‐M. LNT‐DOX was quite slow in a neutral buffer, it was particularly fast in an acidic solution with a pH of 5.0. Compared with DOX , FA ‐M. LNT‐DOX showed higher cytotoxicity in HeLa cells and significantly lower cytotoxicity in normal cells. These results suggested that FA ‐M. LNT‐DOX could be considered as a potential drug delivery candidate for folate receptor‐positive cancer therapy.

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