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Application of N ‐substituted (aminomethyl)benzoate Strategy in Design of Scutellarein Derivatives with Improved Caco‐2 Cell Permeability and In Vitro Antioxidative Activity
Author(s) -
Dai ZeQin,
Su Hang,
Luo Min,
Ou Yu,
Fu XiaoZhong,
Dong YongXi,
Cha YuFeng,
Zhang Shun,
Huang Yong,
Wang YongLin
Publication year - 2015
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10377
Subject(s) - scutellarin , chemistry , nuclear chemistry , reactive oxygen species , aqueous solution , solubility , caco 2 , antioxidant , membrane permeability , in vitro , stereochemistry , membrane , biochemistry , organic chemistry , chromatography
The permeability ( P app AP to BL ) of compound 5e in Caco‐2 cell was 12.0 times and 6.0 times higher than that of scutellarein and scutellarein, respectively. Compound 5e protect against H 2 O 2 ‐induced PC 12 cells’ oxidative damage with more potency than positive controls.