Application of  N ‐substituted (aminomethyl)benzoate Strategy in Design of Scutellarein Derivatives with Improved Caco‐2 Cell Permeability and  In Vitro  Antioxidative Activity | Zendy

Dai ZeQin | Zendy; Su Hang | Zendy; Luo Min | Zendy; Ou Yu | Zendy; Fu XiaoZhong | Zendy; Dong YongXi | Zendy; Cha YuFeng | Zendy; Zhang Shun | Zendy; Huang Yong | Zendy; Wang YongLin | Zendy

Premium

Application of N ‐substituted (aminomethyl)benzoate Strategy in Design of Scutellarein Derivatives with Improved Caco‐2 Cell Permeability and In Vitro Antioxidative Activity

Author(s) -

Dai ZeQin,

Su Hang,

Luo Min,

Ou Yu,

Fu XiaoZhong,

Dong YongXi,

Cha YuFeng,

Zhang Shun,

Huang Yong,

Wang YongLin

Publication year - 2015

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.10377

Subject(s) - scutellarin , chemistry , nuclear chemistry , reactive oxygen species , aqueous solution , solubility , caco 2 , antioxidant , membrane permeability , in vitro , stereochemistry , membrane , biochemistry , organic chemistry , chromatography

The permeability ( P app AP to BL ) of compound 5e in Caco‐2 cell was 12.0 times and 6.0 times higher than that of scutellarein and scutellarein, respectively. Compound 5e protect against H 2 O 2 ‐induced PC 12 cells’ oxidative damage with more potency than positive controls.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research