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Synthesis and Biocompatibility of Silicone Hydrogel Functionalized with Polysaccharide
Author(s) -
Jeong KeunSeung,
Kim HoJoong,
Lim HwaLim,
Ryu GeunChang,
Seo EunSun,
You NamHo,
Jun Jin
Publication year - 2015
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10315
Subject(s) - alginic acid , polydimethylsiloxane , silicone , biocompatibility , protein adsorption , adsorption , polysaccharide , polymer , materials science , surface modification , chemical engineering , wetting , coating , polymer chemistry , chemistry , organic chemistry , nanotechnology , composite material , biochemistry , engineering
A novel methacrylated polydimethylsiloxane was synthesized for the preparation of silicone hydrogel (SiHy). The SiHy was functionalized with polysaccharides such as hyaluronic acid and alginic acid by construction of an interpenetrating polymer network (IPN) structure composed of cross‐linked SiHy backbones and polysaccharide networks. The polysaccharide‐modified SiHys have proven to successfully reduce nonspecific protein adsorption and improve the surface hydrophilicity compared with unmodified SiHy.