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IBX ‐Mediated Oxidation and Internal Redox Reaction Cascade: Asymmetric One‐Pot Synthesis of Ring‐fused Tetrahydroquinolines
Author(s) -
Kim Mi Hyun,
Jeong Hyun Jung,
Kim Dae Young
Publication year - 2015
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10215
Subject(s) - chemistry , redox , ring (chemistry) , cascade reaction , cascade , combinatorial chemistry , hydride , half reaction , catalysis , organic chemistry , chromatography , hydrogen
Organocatalytic asymmetric synthesis of tetrahydroquinolines has been achieved via oxidation and 1,5‐hydride transfer/ring‐closure cascade. The feature of this research is one‐pot transformation of 3‐arylprop‐2‐en‐1‐ol derivatives into tetrahydroquinolines using o ‐iodoxybenzoic acid‐mediated oxidation and internal redox reactions. The synthetically useful ring‐fused tetrahydroquinoline derivatives were obtained in moderate yields and high enantioselectivity.

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