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Loading and Release of Doxorubicin with Magnetic Nanotubes #
Author(s) -
Bai Xia,
Wang Xiang,
English Douglas,
Lee Sang Bok
Publication year - 2015
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10141
Subject(s) - chemistry , doxorubicin , molecule , silane , confocal microscopy , stereochemistry , organic chemistry , physics , medicine , surgery , chemotherapy , optics
In this work, we study magnetic nanotubes ( MNTs ) as drug carriers to control the loading and release of doxorubicin (Dox). The inner surfaces of MNTs where Dox molecules are stored are modified with C18 ‐silane and pyridine–silane. By tuning the interaction between the drug molecules and inner surfaces of MNTs via pH , Dox can be effectively encapsulated at pH 7.2 and released at pH 4.5. The successful loading of Dox is confirmed with confocal microscopy studies. The release profiles of Dox from modified MNTs are detected by spectrofluorophotometry, with bare MNTs as control. With proper modifications, MNTs can be used for pH ‐dependent, controlled release of drug molecules.