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Fabrication of Chitosan‐Gold Nanoshells for γ‐Aminobutyric Acid Detection as a Surface‐enhanced Raman Scattering Substrate
Author(s) -
Lim JaeWook,
Kang IkJoong
Publication year - 2015
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10130
Subject(s) - nanoshell , raman scattering , fiber , calibration curve , chitosan , optical fiber , adsorption , materials science , substrate (aquarium) , raman spectroscopy , aminobutyric acid , chemistry , analytical chemistry (journal) , optics , chromatography , optoelectronics , detection limit , plasmon , composite material , organic chemistry , physics , biochemistry , oceanography , geology , receptor
A surface‐enhanced Raman scattering ( SERS ) principle‐based brain‐probing optical fiber was produced to analyze changes in the concentration of γ‐aminobutyric acid ( GABA ). The procedure was carried out within the GABA administration concentration range of 5–30 mM for the patients who should take cranial medicines for GABA components of less than a normal range. The optical fiber, of which the surface had been reformed, was prepared by treatment with chitosan‐gold nanoshell particles, which were synthesized by using an ionic interaction. The treated fiber was subsequently combined with GABA , for the purpose of analyzing its GABA concentration. The calibration curve of the SERS sensitivity (counts) as determined by the concentration levels of GABA adsorbed onto the chitosan‐gold nanoshell without attachment to the optical fiber was as follows: y = 0.2 x 2 − 0.6743 x + 419.8 ( R 2 = 0.9874), while the corresponding calibration curve of the SERS sensitivity (counts) with attachment to optical fiber was as follows: y = 7.4057 x 2 + 93.68 x + 1851.4 ( R 2 = 0.9472). Based on the aforementioned two sets of data, it was confirmed that the analysis of GABA using optical fiber had a higher level of sensitivity compared to its analysis in the absence of optical fiber.