Soluble Epoxide Hydrolase Inhibitory Constituents from  Selaginella tamariscina | Zendy

Kim Jang Hoon | Zendy; Tai Bui Huu | Zendy; Yang Seo Young | Zendy; Kim Ji Eun | Zendy; Kim Sang Kyum | Zendy; Kim Young Ho | Zendy

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Soluble Epoxide Hydrolase Inhibitory Constituents from Selaginella tamariscina

Author(s) -

Kim Jang Hoon,

Tai Bui Huu,

Yang Seo Young,

Kim Ji Eun,

Kim Sang Kyum,

Kim Young Ho

Publication year - 2015

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.10068

Subject(s) - chemistry , vanillic acid , electrospray ionization , stereochemistry , caffeic acid , epoxide hydrolase 2 , selaginella , circular dichroism , protocatechuic acid , mass spectrometry , biochemistry , organic chemistry , chromatography , antioxidant , enzyme , botany , biology

A novel norneolignan, tamariscinol T ( 1 ), and six known compounds, protocatechuic acid ( 2 ), vanillic acid ( 3 ), caffeic acid ( 4 ), amentoflavone ( 5 ), 2,3‐dihydroamentoflavone ( 6 ), and 2″,3″‐dihydroamentoflavone ( 7 ), were isolated from Selaginella tamariscina. Their structures were elucidated using 1D / 2D NMR , high‐resolution electrospray ionization mass spectrometry ( HR‐ESI‐MS) , and infrared ( IR) , ultraviolet ( UV) , and circular dichroism ( CD) spectroscopy . The effects of the isolated compounds on soluble epoxide hydrolase ( sEH ) activity were then evaluated. Compounds 5–7 potently inhibited sEH activity with IC 50 values of 24.3 ± 1.6, 5.4 ± 0.1, and 11.9 ± 0.1 μM , respectively. In addition, analysis of the kinetics of compounds 5–7 revealed that their inhibitory actions were noncompetitive, with inhibition constants ( K i ) of 24.4 ± 1.2, 8.6 ± 0.4, and 5.3 ± 0.6 μM , respectively.

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