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Synthesis of Pyrazolo[4,3‐ c ]quinolines from Morita–Baylis–Hillman Adducts of 2‐Bromobenzaldehydes
Author(s) -
Yu Jin,
Moon Hye Ran,
Lim Jin Woo,
Kim Jae Nyoung
Publication year - 2015
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.10050
Subject(s) - methyl vinyl ketone , baylis–hillman reaction , chemistry , intramolecular force , adduct , ketone , medicinal chemistry , organic chemistry , stereochemistry , catalysis
The synthesis of pyrazolo[4,3‐ c ]quinolines has been carried out from the Morita–Baylis–Hillman bromides of 2‐bromobenzaldehydes and methyl vinyl ketone. The synthesis involved a novel one‐pot preparation of functionalized pyrazoles from α,β‐enones, a one‐pot Cu‐mediated intramolecular N‐arylation, and the elimination of p ‐toluenesulfinic acid.