Open AccessHealth‐related quality of life among patients with adenocarcinoma of the gastro‐oesophageal junction treated by gastrectomy or oesophagectomy
Author(s) -
Barbour A. P.,
Lagergren P.,
Hughes R.,
Alderson D.,
Barham C. P.,
Blazeby J. M.
Publication year - 2008
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1002/bjs.5912
Subject(s) - medicine , quality of life (healthcare) , gastro , gastrectomy , disease , stage (stratigraphy) , esophagectomy , esophageal disease , cancer , surgery , esophagus , esophageal cancer , reflux , paleontology , nursing , biology
Abstract Background: Tumours of the gastro‐oesophageal junction may be resected by total gastrectomy (TG) or transthoracic oesophagectomy (TTO). This study compared health‐related quality of life (HRQL) following these procedures. Methods: Prospective clinical and HRQL data (European Organization for Research and Treatment of Cancer QLQ‐C30) were collected from 63 consecutive patients (20 TG and 43 TTO) before and 6 months after surgery for Siewert type I–III gastro‐oesophageal tumours. Results: Questionnaire response rates exceeded 90 per cent. Patients were similar with respect to disease stage, treatment‐related mortality and survival, but those selected for TTO were younger with less co‐morbidity than those undergoing TG. These differences were reflected in baseline HRQL scores, which were better in patients selected for TTO. Six months after surgery, however, HRQL showed a greater deterioration after TTO than after TG in terms of role and social function, global quality of life and fatigue. Symptom scores for pain and diarrhoea increased in both groups. Conclusion: TTO had a greater negative impact on HRQL than TG for tumours of the gastro‐oesophageal junction. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.