Randomized open‐label phase  II  study comparing oxycodone–naloxone with oxycodone in early return of gastrointestinal function after laparoscopic colorectal surgery | Zendy

Creamer F. | Zendy; Balfour A. | Zendy; Nimmo S. | Zendy; Foo I. | Zendy; Norrie J. D. | Zendy; Williams L. J. | Zendy; Fearon K. C. | Zendy; Paterson H. M. | Zendy

Open Access

Randomized open‐label phase II study comparing oxycodone–naloxone with oxycodone in early return of gastrointestinal function after laparoscopic colorectal surgery

Author(s) -

Creamer F.,

Balfour A.,

Nimmo S.,

Foo I.,

Norrie J. D.,

Williams L. J.,

Fearon K. C.,

Paterson H. M.

Publication year - 2017

Publication title -

british journal of surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.202

H-Index - 201

eISSN - 1365-2168

pISSN - 0007-1323

DOI - 10.1002/bjs.10322

Subject(s) - medicine , oxycodone , anesthesia , randomized controlled trial , opioid , nausea , vomiting , (+) naloxone , analgesic , clinical endpoint , surgery , receptor

Combined oral modified-release oxycodone-naloxone may reduce opioid-induced postoperative gut dysfunction. This study examined the feasibility of a randomized trial of oxycodone-naloxone within the context of enhanced recovery for laparoscopic colorectal resection.

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