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Continuous capture scale down model: A comparison of a continuous and a discrete approach
Author(s) -
Seidel Jonathan C.,
Göbel Mathias,
Dos Reis Rodrigues Rui C.,
Kaup Nora M.,
Rapp Johanna,
Frauenschuh Achim,
Shultz Joseph,
Cui Huanchun
Publication year - 2021
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.27736
Subject(s) - continuous modelling , continuous production , process engineering , continuous monitoring , scale (ratio) , batch processing , continuous flow , computer science , biological system , biochemical engineering , mathematics , chemical engineering , engineering , biology , physics , mathematical analysis , operations management , quantum mechanics , programming language
In continuous pharmaceutical manufacturing, consisting of a perfused batch fermentation and integrated continuous downstream processing, the continuous capture is the linking unit operation. For the development of this unit operation, scale‐down models (SDMs) are crucial, whereas discrete, noncontinuous SDMs are preferred over continuous SDM due to their simplistic nature, reduced material consumption, and shorter operation time. The results presented in this study show the suitability of a discrete SDM approach, compared to a continuous SDM for a continuous protein A purification step.