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Tissue scaffolds functionalized with therapeutic elastin‐like biopolymer particles
Author(s) -
Bulutoglu Beyza,
Devalliere Julie,
Deng Sarah L.,
Acun Aylin,
Kelangi Sarah S.,
Uygun Basak E.,
Yarmush Martin L.
Publication year - 2020
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.27283
Subject(s) - scaffold , elastin , tissue engineering , drug delivery , wound healing , biopolymer , chemistry , in vivo , microbiology and biotechnology , biomedical engineering , biology , polymer , pathology , immunology , medicine , organic chemistry
Tissue engineering scaffolds are intended to provide mechanical and biological support for cells to migrate, engraft and ultimately regenerate the tissue. Development of scaffolds with sustained delivery of growth factors and chemokines would enhance the therapeutic benefits, especially in wound healing. In this study, we incorporated our previously designed therapeutic particles, composed of fusion of elastin‐like peptides (ELPs) as the drug delivery platform to keratinocyte growth factor (KGF), into a tissue scaffold, alloderm. The results demonstrated that sustained KGF–ELP release was achieved and the bioactivity of the released therapeutic particles was shown via cell proliferation assay, as well as a mouse pouch model in vivo, where higher cellular infiltration and vascularization were observed in scaffolds functionalized with KGF–ELPs.