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Manipulation of micro‐ and nanoparticles in viscoelastic fluid flows within microfluid systems
Author(s) -
Manshadi Mohammad K. D.,
Mohammadi Mehdi,
Monfared Leila Karami,
SanatiNezhad Amir
Publication year - 2020
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.27211
Subject(s) - microfluidics , microchannel , nanotechnology , biological fluids , sorting , viscoelasticity , particle (ecology) , nanoparticle , computer science , materials science , biochemical engineering , chemistry , engineering , biology , chromatography , composite material , ecology , programming language
Manipulation of micro‐ and nanoparticles in complex biofluids is highly demanded in most biological and biomedical applications. A significant number of microfluidic platforms have been developed for inexpensive, rapid, accurate, and efficient particle manipulation. Due to the enormous potential of viscoelastic fluids (VEFs) for particle manipulation, various emerging microfluidic‐based VEFs techniques have been presented over the last decade. This review provides an intuitive understanding of VEF physics for particle separation in different microchannel geometries. Besides, active and passive VEF methods are critically reviewed, highlighting the potential and practical challenges of each technique for particle/cell focusing, sorting, and separation. The outcome of this study could enable recognizing deliverable VEF technology with the promising prospect in the manipulation of submicron biological samples (e.g., exosomes, DNA, and proteins).