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Paper‐based point‐of‐care test with xeno nucleic acid probes
Author(s) -
Hu Jie,
Xiao Kang,
Jin Birui,
Zheng Xuyang,
Ji Fanpu,
Bai Dan
Publication year - 2019
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.27106
Subject(s) - point of care testing , nucleic acid , nanotechnology , bridging (networking) , computer science , systems engineering , point of care , biochemical engineering , chemistry , engineering , medicine , materials science , biochemistry , pathology , computer network
Bridging the unmet need of efficient point‐of‐care testing (POCT) in biomedical engineering research and practice with the emerging development in artificial synthetic xeno nucleic acids (XNAs), this review summarized the recent development in paper‐based POCT using XNAs as sensing probes. Alongside the signal transducing mode and immobilization methods of XNA probes, a detailed evaluation of probe performance was disclosed. With these new aspects, both researchers in synthetic chemistry / biomedical engineering and physicians in clinical practice could gain new insights in designing, manufacturing and choosing suitable reagents and techniques for POCT.