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Multiscale dynamic modeling and simulation of a biorefinery
Author(s) -
Ploch Tobias,
Zhao Xiao,
Hüser Jonathan,
Lieres Eric,
HannemannTamás Ralf,
Naumann Uwe,
Wiechert Wolfgang,
Mitsos Alexander,
Noack Stephan
Publication year - 2019
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.27099
Subject(s) - biorefinery , modelica , computer science , process (computing) , dynamic simulation , modeling and simulation , flux balance analysis , toolbox , process modeling , biochemical engineering , simulation , raw material , environmental science , process optimization , engineering , ecology , chemistry , programming language , biochemistry , environmental engineering , biology
A biorefinery comprises a variety of process steps to synthesize products from sustainable natural resources. Dynamic plant‐wide simulation enhances the process understanding, leads to improved cost efficiency and enables model‐based operation and control. It is thereby important for an increased competitiveness to conventional processes. To this end, we developed a Modelica library with replaceable building blocks that allow dynamic modeling of an entire biorefinery. For the microbial conversion step, we built on the dynamic flux balance analysis (DFBA) approach to formulate process models for the simulation of cellular metabolism under changing environmental conditions. The resulting system of differential‐algebraic equations with embedded optimization criteria (DAEO) is solved by a tailor‐made toolbox. In summary, our modeling framework comprises three major pillars: A Modelica library of dynamic unit operations, an easy‐to‐use interface to formulate DFBA process models and a DAEO toolbox that allows simulation with standard environments based on the Modelica modeling language. A biorefinery model for dynamic simulation of the OrganoCat pretreatment process and microbial conversion of the resulting feedstock by Corynebacterium glutamicum serves as case study to demonstrate its practical relevance.