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Advancements in the design and scalable production of viral gene transfer vectors
Author(s) -
Sharon David,
Kamen Amine
Publication year - 2018
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.26461
Subject(s) - viral vector , biopharmaceutical , vector (molecular biology) , lentivirus , virology , genetic enhancement , safer , technology transfer , gene transfer , computational biology , microbiology and biotechnology , biology , computer science , virus , gene , viral disease , genetics , knowledge management , computer security , recombinant dna
The last 10 years have seen a rapid expansion in the use of viral gene transfer vectors, with approved therapies and late stage clinical trials underway for the treatment of genetic disorders, and multiple forms of cancer, as well as prevention of infectious diseases through vaccination. With this increased interest and widespread adoption of viral vectors by clinicians and biopharmaceutical industries, there is an imperative to engineer safer and more efficacious vectors, and develop robust, scalable and cost‐effective production platforms for industrialization. This review will focus on major innovations in viral vector design and production systems for three of the most widely used viral vectors: Adenovirus, Adeno‐Associated Virus, and Lentivirus.