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Bone tissue bioprinting for craniofacial reconstruction
Author(s) -
Datta Pallab,
Ozbolat Veli,
Ayan Bugra,
Dhawan Aman,
Ozbolat Ibrahim T.
Publication year - 2017
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.26349
Subject(s) - craniofacial , soft tissue , bone tissue , hard tissue , medicine , biomedical engineering , surgery , psychiatry
Craniofacial (CF) tissue is an architecturally complex tissue consisting of both bone and soft tissues with significant patient specific variations. Conditions of congenital abnormalities, tumor resection surgeries, and traumatic injuries of the CF skeleton can result in major deficits of bone tissue. Despite advances in surgical reconstruction techniques, management of CF osseous deficits remains a challenge. Due its inherent versatility, bioprinting offers a promising solution to address these issues. In this review, we present and analyze the current state of bioprinting of bone tissue and highlight how these techniques may be adapted to serve regenerative therapies for CF applications. Biotechnol. Bioeng. 2017;114: 2424–2431. © 2017 Wiley Periodicals, Inc.