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Modeling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger: I. Model definition and stability of the steady state
Author(s) -
Torres Néstor V.
Publication year - 1994
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260440115
Subject(s) - aspergillus niger , citric acid , steady state (chemistry) , biochemistry , metabolism , chemistry , stability (learning theory) , representation (politics) , carbohydrate metabolism , biological system , biochemical engineering , biology , computer science , engineering , organic chemistry , machine learning , politics , political science , law
A model of the carbohydrate metabolism and the anaplerotic synthesis of oxalacetate in Aspergillus niger , under conditions of citric and accumulation, is presented. In this first article we set the stage for subsequent analysis within the framework of the biochemical system theory (BST): we formulate the model and develop the system representation in power law forms, showing that the steady state is locally stable. In the second article, the control structure of the system is described and a rationale for the optimization of the process is developed. © 1994 John Wiley & Sons, Inc.