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Review: Tissue engineering in the nervous system
Author(s) -
Bellamkonda Ravi,
Aebischer Patrick
Publication year - 1994
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260430703
Subject(s) - neurochemical , neuroscience , neural engineering , neural tissue engineering , tissue engineering , nervous system , neural cell , regeneration (biology) , central nervous system , computer science , nanotechnology , biology , engineering , biomedical engineering , cell , materials science , microbiology and biotechnology , biochemistry
The nervous system presents a challenge to the field of tissue engineering because some of its complex neurochemical and neuroanatomical architecture is just beginning to be understood. A combination of advances in molecular neurobiology, gene transfer techniques, and the concomitant advances in the engineering of biomaterials at a molecular level, are making tissue engineering in the nervous system possible. Due to the vast range of fields that this highly interdisciplinary task spans, any review is bound to be somewhat limited. Given that, this review attempts to cover some solutions engineered for: (a) the functional replacement of a missing neuroactive component; (b) the rescue or regeneration of degenerated neural tissue; and (c) the building of intelligent neural cell‐based biosensors and simple in vitro neural circuits based on controlled neural cell attachment to electrically relevant substrates. © 1994 John Wiley & Sons, Inc.