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Effect of solvent on enantioselective esterification of naproxen by lipase with trimethylsilyl methanol
Author(s) -
Tsai ShauWei,
Wei HwaJou
Publication year - 1994
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260430109
Subject(s) - chemistry , lipase , naproxen , methanol , enantioselective synthesis , yield (engineering) , trimethylsilyl , alcohol , organic chemistry , stereoselectivity , solvent , toluene , triacylglycerol lipase , resolution (logic) , chromatography , catalysis , enzyme , medicine , materials science , alternative medicine , pathology , metallurgy , artificial intelligence , computer science
Improvement of stereoselective resolution of racemic Naproxen, 2‐(6‐methoxy‐2‐naphthyl)propionic acid, was attempted with esterifcation reaction by Candida cylindracea lipase. By carefully selecting the organic medium, a 72‐time enhancement of yield of the desired S‐ester was achieved. The optimal reaction temperature was approximately 53°C, and an alcohol concentration between 20 m M and 40 m M in an 80% (v/v) isooctane and 20% (v/v) toluene mixture was found. © 1994 John Wiley & Sons, Inc.