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Optimization of fed‐batch fermentors by iterative dynamic programming
Author(s) -
Luus Rein
Publication year - 1993
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260410513
Subject(s) - dynamic programming , computer science , mathematical optimization , biochemical engineering , biological system , mathematics , biology , engineering
By using penalty functions to handle state constraints, iterative dynamic programming can be used in a straightforward manner for the optimization of fedbatch fermentors. No computational difficulties were encountered and better results are obtained than previously reported in the literature for a fed‐batch fermentor for biosynthesis of penicillin. © 1993 Johy Wiley & Sons, Inc.