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Performances of aseptic sampling devices for on‐line monitoring of fermentation processes
Author(s) -
Picque D.,
corrieu G.
Publication year - 1992
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260400808
Subject(s) - chromatography , fermentation , filtration (mathematics) , aseptic processing , chemistry , membrane filter , bioreactor , sampling (signal processing) , ethanol , ethanol fermentation , filter (signal processing) , analytical chemistry (journal) , pulp and paper industry , membrane , biochemistry , computer science , food science , mathematics , organic chemistry , engineering , statistics , computer vision
Two liquid sampling systems, which are set in the bioreactor and can be sterilized in place, are described. They are composed primarily of an inorganic membrane filter which is either stationary or is set in a rotating motion. These systems have been tested during three types of fermentation processes (ethanol, lactic acid, and polysaccharide productions). The rotating system gave better filtration performances than the stationary sampler which can be used only in alcoholic fermentation. The rotating sampler was coupled with a high‐pressure liquid chromatograph for the on‐line quantitation of the major compounds present in the filtrate. The results are in good agreement with those obtained from off‐line analysis on samples taken manually. © 1992 John Wiley & Sons, Inc.