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Modeling high‐biomass‐density cell recycle fermentors
Author(s) -
Monbouquette Harold G.
Publication year - 1992
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260390504
Subject(s) - biomass (ecology) , volume fraction , volume (thermodynamics) , conservation of mass , yeast , fermentation , biological system , steady state (chemistry) , chemistry , biochemical engineering , mechanics , thermodynamics , physics , biology , ecology , food science , engineering , biochemistry
Since intrinsic models, which take into account cell volume fraction, follow from proper application of the law of conservation of mass to a multiphase system, the intrinsic modeling approach should be used whenever biomass occupies a significant volume fraction of the culture. A recent report 11 offers the first comparison of intrinsic and nonintrinsic model predictions to actual experimental data gathered from a high‐density yeast recycle fermentor. Here, the analysis of Jarzebski et al. 11 has been carried further to show that the improper nonintrinsic model predicts a steady‐state culture glucose concentration that differs from that given by the fundamentally correct intrinsic model by over 60% at the optimal, bleed stream flow rate. In addition, a revised formulation for an intrinsic ethanol mass balance is presented.